A computer implemented method, a method and a system

A computer implemented method of identifying changes in a subject's heart or an adjacent region over time, the method comprising:

• receiving a set of imaging data relating to a subject's heart, the set of imaging data comprised of images of the subject's heart obtained at a plurality of points in time;
• generating an anatomical model of the subject's heart for a plurality of the images in the set of imaging data so as to provide a set of anatomical models of the subject's heart corresponding to a plurality of points in time;
• aligning a plurality of the anatomical models in the set of anatomical models relative to one another so as to provide a set of aligned data;
• identifying changes in at least one region of the subject's heart by comparing data in the set of aligned data using the machine learning model;
• and
• generating an output that is a prediction relating to an onset of a cardiovascular condition.