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US 2025/0052768 A1Published application
In vitro methods for detecting dll1
OwnerKlaus Heeg, Markus A. Weigand +2inventors
InventorsKlaus Heeg, Markus A. Weigand, Dagmar Hildebrand, Florian Uhle
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Abstract
The invention relates to in vitro methods for detecting Delta-like 1 (DLL1) protein using an anti-DLL 1 capture antibody and a labeled anti-DLL1 detection antibody. According to the invention, these antibodies can be used in an in vitro method to diagnose a severe infection, in particular a sepsis.
Claims10
An in vitro method for detecting Delta-like 1 (DLL1) protein using
- a. a labeled anti-DLL1 detection antibody, or
- b. an anti-DLL1 capture antibody, or
- c. a labeled anti-DLL1 detection antibody and an anti-DLL1 capture antibody
- wherein the labeled anti-DLL1 detection antibody and/or the anti-DLL1 capture antibody are selected from the group consisting of:
- i) an isolated antibody or antigen-binding portion thereof comprising at least one complementary determining region (CDR) amino acid sequence selected from SEQ ID NOs.:
- 1-6;
- and
- ii) an isolated antibody or antigen-binding portion thereof comprising at least one CDR amino acid sequence selected from SEQ ID NOs.:
- 7-12.
6 more elements
Dependencies are inferred from the claim text.