Receptor for vista
AssigneePierre Fabre Medicament
InventorsPierre FERRÉ, Francisco CRUZALEGUI, Noureddine LOUKILI, Olivier DELFOUR, Edward Thein Htun VAN DER HORST
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Abstract
The present disclosure provides methods for modulating (e.g., preventing, inhibiting, blocking) the interaction of PSGL-1 and VISTA with agents (e.g., antibodies) that bind to PSGL-1 and/or VISTA.
Claims10
1-13. (canceled)
An anti-VISTA antibody, or antigen-binding fragment thereof, comprising a heavy chain comprising 3 CDRs of sequences SEQ ID Nos:
- 7, 31, and 15, as defined by Kabat;
- and a light chain comprising 3 CDRs of sequences SEQ ID Nos:
- 19, 23, and 26, as defined by Kabat.
The anti-VISTA antibody of claim 1, wherein said anti-VISTA antibody is a humanized antibody.
The anti-VISTA antibody of claim 1, wherein said anti-VISTA antibody comprises a heavy chain comprising a VH of SEQ ID NO:
- 36;
- and a light chain comprising a VL of SEQ ID NO:
- 30.
Dependencies are inferred from the claim text.