Back to results
US 2025/0052737 A1Published application
Trigger-assembled membrane-spanning nucleic acid nanostructures
OwnerStefan HOWORKA, Conor LANPHEREinventors
Life of this patent
Estimating the term…
Abstract
A nucleic acid nanostructure is provided that comprises a plurality of component modules, each component module comprising a nucleic acid sequence and at least one membrane anchor. The plurality of component modules are capable of undertaking a controlled assembly in response to an external stimulus to form the nanostructure and also to penetrate a semifluid membrane upon or following the controlled assembly. Methods of assembling the nanostructure as well as uses in sensors, drug delivery and release of imaging substances are also provided.
Claims30
A nucleic acid nanostructure comprising:
- a plurality of component modules, each component module comprising a nucleic acid sequence and at least one membrane anchor, and
- wherein the plurality of component modules are capable of undertaking a controlled assembly in response to an external stimulus to form the nanostructure;
- and
- wherein the nanostructure is configured to penetrate a semifluid membrane upon or following the controlled assembly.
1 more element
A nucleic acid nanostructure comprising:
- a plurality of component modules, each component module comprising a deoxyribonucleic acid (DNA) sequence, wherein the DNA sequence comprises at least a portion of double helix that defines a secondary structure and at least a portion of single stranded sequence that defines an assembly interface, and at least one hydrophobic anchor;
- and
- a plurality of single stranded nucleic acid lock sequences that are capable of hybridising with the single stranded sequence of the assembly interface;
- wherein the component modules are able to associate and interact with a surface of a semifluid membrane via the anchor, and
- wherein the modules are capable of undertaking a controlled assembly in response to an externally applied stimulus that initiates disassociation of the plurality of lock sequences to reveal the assembly interfaces thereby allowing the plurality of component modules to associate and thereby form a nanostructure.
2 more elements
Dependencies are inferred from the claim text.