Apparatus and methods of sublimation for repeatable uniform or patterned deposition of matrix crystals on solid substrates
AssigneeVanderbilt University
InventorsDavid ANDERSON, Eric SPIVEY, Richard CAPRIOLI
Life of this patent
Estimating the term…
Abstract
This disclosure relates to apparatus and methods for sublimation and deposition of chemicals. In particular aspects, this disclosure relates to apparatus and methods for patterned sublimation and deposition of chemicals for use in matrix assisted laser desorption ionization imaging mass spectrometry (MALDI IMS). In specific aspects, the apparatus comprises a vacuum chamber and a template comprising a planar surface containing the chemical to be sublimed, where the template is located within the vacuum chamber.
Claims23
An apparatus for sublimation and deposition of a chemical, the apparatus comprising:
- a vacuum chamber where in operation the chamber is below atmospheric pressure;
- a template comprising a planar surface containing the chemical to be sublimed, wherein the template is located within the vacuum chamber;
- a heating element configured to heat the template and sublimate the chemical on the planar surface of the template;
- a substrate retaining device;
- and
- a surface in contact with the substrate retaining device, wherein:
- the planar surface of the template is an insert placed into a pan structure;
- the substrate retaining device is located within the vacuum chamber;
- the surface in contact with the substrate retaining device is held at a lower temperature than the template when the template is heated by the heating element;
- and
- the substrate retaining device is configured to position a substrate such that compound sublimated from the planar surface of the template can be deposited on the substrate.
(canceled)
19-20. (canceled)
24-33. (canceled)
Dependencies are inferred from the claim text.