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AssigneeThe Johns Hopkins University
InventorRanjan J. Perera
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The present invention relates to the field of cancer. More specifically, the present invention provides methods and compositions useful for detecting and treating prostate cancer. In a specific embodiment, a method for identifying a patient as having aggressive prostate cancer comprising the step of detecting overexpression relative to a control of epithelial cell adhesion molecule (EpCAM), H4 clustered histone 5 (H4C5), and tetratricopeptide repeat domain 3 (TTC3) in a urine sample obtained from the patient. In a more specific embodiment, the detecting step comprises detecting protein or ribonucleic acid (RNA) level of EPCAM, H4C5 and TTC3. In another specific embodiment, the method further comprises detecting overexpression relative to a control of one or more of messenger ribonucleic acid (mRNA), circulating RNA (circRNA), extracellular DNA and long non-coding RNA (lncRNA). The method can further comprise detecting metabolites.
A method for identifying a patient as having aggressive prostate cancer comprising the step of detecting overexpression relative to a control of epithelial cell adhesion molecule (EpCAM), H4 clustered histone 5 (H4C5), and tetratricopeptide repeat domain 3 (TTC3) in a sample obtained from the patient.
A method for treating a patient having aggressive prostate cancer comprising the step of administering a prostate cancer therapy to a patient identified as having overexpression of EPCAM, H4C5 and TTC3 in a sample relative to a control.
A method for identifying a patient as having aggressive prostate cancer comprising the step of detecting the overexpression of one or more of protein, mRNA, circRNA, eccDNA lncRNA in a sample obtained from the patient relative to a control.
Dependencies are inferred from the claim text.