Supramolecular encapsulated dna/rna particles
AssigneeYeda Research and Development Co. Ltd.
InventorsSergey N. SEMENOV, Ekaterina V. SKORB
Life of this patent
Estimating the term…
Abstract
Provided herein a supramolecular assembly comprising a solid porous particle comprising a single-stranded polynucleotide encapsulated by non-covalent organic structure. Specifically, the non-covalent organic structure is melamine-cyanurate, and the single-stranded polynucleotide is ssDNA or ssRNA.
Claims32
A supramolecular assembly comprising a solid porous particle comprising a plurality of single-stranded polynucleotides encapsulated by non-covalent organic structure.
(canceled)
(canceled)
(canceled)
-18. (canceled)
(canceled)
A method of detecting the presence of a nucleotide sequence in a sample, the method comprising:
- a. obtaining a sample;
- b. contacting the sample with a supramolecular assembly comprising a solid porous particle comprising a plurality of single-stranded polynucleotides encapsulated by non-covalent organic structure;
- c. adjusting the pH of the solution for dissolution of particles;
- and
- d. detecting the presence of a nucleotide sequence.
(canceled)
(canceled)
A method of gene suppression in a cell, the method comprising:
- contacting the cell with a supramolecular assembly comprising a solid porous particle comprising a plurality of single-stranded polynucleotides encapsulated by non-covalent organic structure.
A method of expressing a gene in a cell, the method comprising:
- contacting the cell with a supramolecular assembly comprising a solid porous particle comprising a plurality of single-stranded polynucleotides encapsulated by non-covalent organic structure.
Dependencies are inferred from the claim text.