Membrane-embedded nanopore and uses thereof
AssigneeArizona Board of Regents on behalf of Arizona State University
InventorsHao YAN, Swarup DEY, Fei ZHENG
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Abstract
A nanostructure comprising: a) a base plate sheet comprising a single-duplex layer comprised of DNA origami configured in a planar arrangement, b) a pore configured within the center of the base plate sheet, and c) a multi-duplex layer-thick wall comprising a single-duplex layer comprised of DNA origami that extends downward from the base plate sheet on the periphery of the pore, wherein the base plate sheet comprises a single-stranded DNA region on the bottom surface for lipid membrane anchor modification.
Claims31
A nanostructure comprising:
- a) a base plate sheet comprising a single-duplex layer comprised of DNA origami that is configured in a planar arrangement,
- b) a pore configured within the center of the base plate sheet, and
- c) a multi-duplex layer-thick wall comprising a single-duplex layer comprised of DNA origami that extends downward from the base plate sheet on the periphery of the pore, wherein the base plate sheet comprises a single-stranded DNA region on the bottom surface.
- d) a lipid membrane anchor covalently linked to a single-stranded DNA sequence which is partially complementary to the single-stranded DNA region of the base plate sheet on the bottom surface.
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The nanostructure of claim 3, wherein the lipid membrane anchor is selected from cholesterol, or a fatty alcohol.
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Dependencies are inferred from the claim text.