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US 2025/0051798 A1Published application
Rna construct
AssigneesImperial College Innovations Limited, VaxEquity Ltd
InventorsPaul McKay, Robin Shattock
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Abstract
The invention relates to RNA constructs, and particularly, although not exclusively, to mRNA constructs and saRNA replicons and to nucleic acids and expression vectors encoding such RNA constructs. The invention extends to the use of such RNA constructs in therapy, for example in treating diseases and/or in vaccine delivery. The invention extends to pharmaceutical compositions comprising such RNA constructs, and methods and uses thereof.
Claims21
A recombinant RNA construct encoding:
- (a) (i) at least one therapeutic biomolecule;
- (ii) at least one immune stimulatory protein (ISP), and
- optionally (iii) at least one human innate modulatory protein (IMP) and/or at least one viral immune inhibitor protein (IIP);
- or
- (b) (i) at least one immune stimulatory protein (ISP);
- and/or
- (ii) at least one human innate modulatory protein (IMP) and/or at least one viral immune inhibitor protein (IIP).
4 more elements
21-29. (canceled)
Dependencies are inferred from the claim text.