METHODS AND COMPOSITIONS RELATED TO RNA-TARGETED RHO SMALL GTPase RND3/RhoE THERAPY
AssigneeThe Texas A&M University System
InventorsJiang Chang, Weijia Luo
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Abstract
Disclosed are RNA inhibitors, such as small interfering RNAs (siRNAs) and short hairpin RNAs (shRNAs) specific for RND3, alternatively referred to as RhoE. Also disclosed are methods of treating subjects by administering RNA inhibitors. Further disclosed are methods of detecting potential modulators of RND3.
Claims4
An isolated nucleic acid molecule, wherein said molecule comprises 90% or more identity to SEQ ID NO:
- 1, SEQ ID NO:
- 2, SEQ ID NO:
- 3, or SEQ ID NO:
- 4.
A composition comprising a) an isolated nucleic acid molecule comprising 90% or more identity to SEQ ID NO:
- 1;
- and b) an isolated nucleic acid molecule comprising 90% or more identity to SEQ ID NO:
- 2.
A composition comprising a) an isolated nucleic acid molecule comprising 90% or more identity to SEQ ID NO:
- 3;
- and b) an isolated nucleic acid molecule comprising 90% or more identity to SEQ ID NO:
- 4.
4-64. (canceled)
Dependencies are inferred from the claim text.