Dnazyme and use thereof
AssigneeShanghai Cangyu Biotechnology Co., Ltd
InventorsHongzhou GU, Qiao ZHANG, Kai XIA, Fuyou LI
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Abstract
The present disclosure provides a DNAzyme and use thereof. The present disclosure also provides a system, comprising one or more catalytic domains and one or more substrate domains.
Claims45
A system, comprising one or more catalytic domains and one or more substrate domains, wherein said catalytic domains comprise 13PD catalytic domain sequence, said catalytic domains cleave said substrate domains at a cleavage site, and said substrate domains comprise a base selected from the group consisting of A, C, and G on 3′ side of said cleavage site.
A nucleic acid, comprising one or more catalytic domains and one or more substrate domains, wherein said catalytic domains comprise 13PD catalytic domain sequence, said catalytic domains cleave said substrate domains at a cleavage site, and said substrate domains comprise a base selected from the group consisting of A, C, and G on 3′ side of said cleavage site.
A combination, comprising providing a condition comprising about 1 to 2 mM Zn2+, and about 5 to 20 mM Mn2+.
Dependencies are inferred from the claim text.