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AssigneeLeibniz-Institut FüR Polymerforschung Dresden E. V
InventorsElisha KRIEG, Yu-Hsuan PENG, Krishna GUPTA, Syuan Ku HSIAO
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A modifiable hydrogel material has main chain polymers which are modified with anchor modules in the form of predetermined functionalized single strands of DNA. The main chain polymers can be crosslinked with one another by intermolecular DNA double strand formation. A DNA sequence of the anchor modules has a predetermined number of specific sequence positions N with different base combinations and/or is blocked by a temperature-dependent DNA blocking strand. In a method for producing a hydrogel with the modifiable hydrogel material, DNA modules in the form of free DNA single strands or DNA modules in the form of predetermined DNA single strand pairs which bind to anchor modules in a complementary manner are employed for crosslinking the main chain polymers, which form an intermolecular DNA double strand at a common binding domain.
A modifiable hydrogel material comprises:
(canceled)
A method for producing a hydrogel with a hydrogel material having main chain polymers which are modified with anchor modules in the form of predetermined functionalised DNA single strands, comprising crosslinking the main chain polymers with one another by intermolecular DNA double strand formation, wherein DNA modules in the form of free DNA single strands or DNA modules in the form of predetermined DNA single strand pairs which bind to the anchor modules in a complementary manner are used for crosslinking the main chain polymers, wherein the free DNA single strands or DNA modules at a common binding domain form an intermolecular DNA double strand, wherein each DNA single strand has an identical anchor module binding domain which binds to the anchor module of a main chain polymer and forms an intermolecular DNA double strand.
-27. (canceled)
Dependencies are inferred from the claim text.