Rhodamine-methylene blue derivative fluorescent probe and preparation method and application thereof

Abstract

A rhodamine-methylene blue derivative fluorescent probe and its preparation method and application are in the technical field of organic synthesis. The rhodamine-methylene blue derivative fluorescent probe has available raw materials and a simple prepared method; the rhodamine-methylene blue derivative fluorescent probe can detect ClO− and ATP in cells by synchronized dual-channel fluorescence, with a detection limit of 0.90 nM for the ClO− and 23.60 nM for the ATP, and thus the rhodamine-methylene blue derivative fluorescent probe can be used for fluorescence quantitative detection of the ClO− and the ATP, and can also be used for simultaneous fluorescence imaging of ClO− and ATP in drug-stimulated cells. Therefore, the rhodamine-methylene blue derivative fluorescent probe has a wide range of potential applications.

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