Solution electrospun fibers, compositions comprising the same and a process of manufacturing thereof
AssigneeUniversiteit Gent
InventorsRichard HOOGENBOOM, Chris VERVAET, Jana BECELAERE, Karen DE CLERCK
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Abstract
The present invention relates to solution electrospun fibers comprising a ingredient in an amorphous form, compositions and their manufacturing process thereof. More specifically, the present invention relates to solution electrospun fibers and a compositions comprising at least one of said fibers, said fiber obtained by solution electrospinning a ingredient with a polymer.
Claims15
A process of manufacturing a solution electrospun fiber, comprising the steps of:
- a) providing a solution comprising an ingredient, a polymer and a solvent;
- b) electrospinning the solution provided at step a) thereby obtaining a solution electrospun fiber comprising an amorphous form of the ingredient;
- wherein step a) comprises providing the polymer at a concentration in said solution which is lower than the concentration at which the polymer is solution electrospinnable into fibers in the absence of the ingredient.
The process according to any one of the previous claims, wherein at step a) the polymer is a poly(2-alkyl-2-oxazoline) (PAOx), preferably poly(2-ethyl-2-oxazoline) (PEtOx).
The process according to any one of the previous claims, wherein at step a) the ingredient and the polymer are selected from those providing a mixture consisting of said ingredient and polymer yielding a solution electrospun fiber having a glass transition temperature Tg of at least about 25° C.
The process according to any one of the previous claims, wherein at step a) the ingredient is provided in an amount of at least 55% w/w, at least 60% w/w, at least 65% w/w, at least 70% w/w of ingredient to polymer.
The process according to any one of the previous claims, wherein at step a) the polymer is a water-soluble polymer.
The process according to any one of the previous claims, wherein at step a) the solvent comprises an acid.
A solution electrospun fiber comprising:
- an ingredient in an amorphous form;
- a polymer;
- wherein the solution electrospun fiber is electrospun from a polymer solution comprising a polymer at a concentration in said solution which is lower than the concentration at which the polymer is solution electrospinnable in the absence of the ingredient.
Dependencies are inferred from the claim text.