alpha-OLEFIN MALEIC ACID OR MALEIMIDE COPOLYMERS FOR ENHANCED BIOACTIVITY

A α-olefin maleic acid copolymer lipid particle comprising:

• a lipid from a phospholipid rich membrane or a galactolipid rich membrane- and a modified maleic acid copolymer comprising:
• a general formula I
• wherein x is in a range of 1 to 19;
• y and z have a ratio in a range of 0.25:1 to 8:1;
• n yields a copolymer having an average molecular weight of less than 500 kg/mol;
• and R1 is selected from the group consisting of
• ii. an alkane chain, optionally, containing or terminating with a cyclic carbon,
• xix. a linear chain alkoxy alkane of the formula —(CH2)qO(CH2)rCH3 where q is 1 to 5 and r is 1 to 15,
• xx. an alkoxy alkane containing or terminating with a cyclic carbon chain,
• xxi. a halogenated alkane,
• xxii. a halogenated cycloalkane,
• xxiii. a halogenated arene,
• xxiv. a chain containing a repeating sequence of (CH2CH2O)t terminating with —OR2 wherein t equals a value of 1 to 50 and R2 is hydrogen, a linear alkane, a cyclic alkane, a trifluoromethyl, a halogenated alkane, a halogenated cycloalkane, or a halogenated arene,
• xxv. a hydrogen, and
• xxvi. mixtures thereof:
• or a general formula II
• wherein x is in a range of 1 to 19;
• y and z have a ratio in a range of 0.25:1 to 8:1;
• n yields a copolymer having an average molecular weight of less than 500 kg/mol;
• and R1 and R4 are both selected from the group consisting of
• i. a linear alkane chain, optionally, containing or terminating with a cyclic carbon,
• ii. a linear chain alkoxy alkane of the formula —(CH2)qO(CH2)rCH3 where q is 1 to 5 and r is 1 to 15,
• iii. an alkoxy alkane containing or terminating with a cyclic carbon chain,
• iv. a halogenated alkane,
• v. a halogenated cycloalkane,
• vi. a halogenated arene,
• vii. a chain containing a repeating sequence of (CH2CH2O)t terminating with —OR5 wherein t equals a value of 1 to 50 and R5 is hydrogen, a linear alkane, a cyclic alkane, a trifluoromethyl, a halogenated alkane, a halogenated cycloalkane, or a halogenated arene,
• viii. a hydrogen, and
• ix. mixtures thereof, and
• R1 and R4 are the same or different.

An α-olefin-co-maleimide copolymer comprising:

• a general formula II
• wherein x is in a range of 1 to 19;
• y and z have a ratio in a range of 0.25:1 to 8:1;
• n yields a copolymer having an average molecular weight of less than 500 kg/mol;
• and R1 and R2 are both selected from the group consisting of
• x. a linear alkane chain, optionally, containing or terminating with a cyclic carbon,
• xi. a linear chain alkoxy alkane of the formula —(CH2)qO(CH2)rCH3 where q is 1 to 5 and r is 1 to 15,
• xii. an alkoxy alkane containing or terminating with a cyclic carbon chain,
• xiii. a halogenated alkane,
• xiv. a halogenated cycloalkane,
• xv. a halogenated arene,
• xvi. a chain containing a repeating sequence of (CH2CH2O)t terminating with —OR2 wherein t equals a value of 1 to 50 and R2 is hydrogen, a linear alkane, a cyclic alkane, a trifluoromethyl, a halogenated alkane, a halogenated cycloalkane, or a halogenated arene,
• xvii. a hydrogen, and
• xviii. mixtures thereof, and
• R1 and R2 are the same or different.