Bispecific molecules to target the first cell
AssigneeThe Trustees of Columbia University in the City of New York
InventorsAzra RAZA, Abdullah M. ALI
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Abstract
The subject matter described herein relates to a method of treating cancer in a subject in need thereof using a bispecific molecule recognizing two antigen markers of different tissue lineages on the surface of The First Cell.
Claims107
A bispecific molecule comprising at least two antigen binding regions, wherein each antigen binding region binds a different antigen on The First Cell (TFC) of a cancer.
A method of treating or preventing cancer in a subject in need thereof, the method comprising administering to the subject a bispecific molecule comprising at least two antigen binding regions, wherein each antigen binding region binds a different antigen on The First Cell (TFC) of a cancer.
An engineered cell expressing at least one marker of epithelial cell lineage and at least one marker of macrophage cell lineage.
A method of diagnosing cancer, wherein the method comprises detecting a cell expressing at least one marker of epithelial cell lineage and at least one marker of macrophage cell lineage.
Dependencies are inferred from the claim text.