Antibodies and uses thereof
OwnerBarbel Schrofelbauer, Patrick Kimes +1inventors
InventorsBarbel Schrofelbauer, Patrick Kimes, William Hahn
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Abstract
Aspects of the invention are drawn to a recombinant monoclonal antibodies and methods of using the same.
Claims40
An isolated monoclonal antibody or fragment thereof, wherein the monoclonal antibody comprises a heavy chain variable region (VH) comprising an amino acid sequence about 90% identical to:
- a-BCAM VHH(6N2_22)
- (SEQ ID NO:
- [ ])
- QVQLVESGGGLVQPGGSLRLSCAASGFTESSYAMSWVRQAPGKGPEWVSA
- INSGGGSTSYADSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCAKSW
- TVRIGQIYHHPTDYWGQGTQVTVSS.
An isolated monoclonal antibody or fragment thereof, wherein the monoclonal antibody comprises heavy chain variable region (VH) comprising three complementarity determining regions (CDRs), wherein CDR1 comprises the amino acid sequence GFTFSSYA, wherein CDR2 comprises the amino acid sequence INSGGGSTS, and wherein CDR3 comprises the amino acid sequence AKSWTVRIGQIYHHPTDY, or sequences that are 90% identical thereto.
Dependencies are inferred from the claim text.