Antibody against ox40 and medical use thereof
OwnerJunzhuan QIU, Zhongliang LI +6inventors
InventorsJunzhuan QIU, Zhongliang LI, Kai SUN, Junyong CHEN, Jian SUN, Zhensheng WANG, Rulei CHEN, Mingde XIA
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Abstract
The present invention relates to the technical field of immunotherapy and molecular immunology, in particular to an antibody against OX40 and the medical use. Provided in the present invention is a specific antibody or an antigen binding fragment thereof, which has a high affinity to OX40 and can block the interaction and signaling of OX40/OX40L.
Claims20
An antibody or an antigen-binding fragment thereof, configured to recognize OX40, comprising heavy chain complementarity-determining regions HCDR1, HCDR2, and HCDR3, and light chain complementarity-determining regions LCDR1, LCDR2, and LCDR3, wherein amino acid sequences of HCDR1, HCDR2, HCDR3, LCDR1, LCDR2, and LCDR3 are selected from one of complementarity-determining region combinations designated as a to f:
- Combination
- name
- HCDR1
- HCDR2
- HCDR3
- LCDR1
- LCDR2
- LCDR3
- a
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 13
- NO:
- 14
- NO:
- 15
- NO:
- 16
- NO:
- 17
- NO:
- 18
- b
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 19
- NO:
- 20
- NO:
- 21
- NO:
- 22
- NO:
- 23
- NO:
- 24
- c
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 25
- NO:
- 8
- NO:
- 9
- NO:
- 37
- NO:
- 38
- NO:
- 39
- d
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 10
- NO:
- 11
- NO:
- 12
- NO:
- 40
- NO:
- 41
- NO:
- 42
- e
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 13
- NO:
- 14
- NO:
- 15
- NO:
- 43
- NO:
- 44
- NO:
- 45
- f
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- SEQ ID
- NO:
- 16
- NO:
- 17
- NO:
- 18
- NO:
- 46
- NO:
- 47
- NO:
- 48
Dependencies are inferred from the claim text.