Wnt-surrogate agents and methods for lacrimal gland regeneration
AssigneeSurrozen Operating, Inc.
InventorsYang LI, Huy Tuan NGUYEN, Yorick POST, Wen-Chen YEH
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Abstract
Methods and compositions for treatment of dry-eye disorders are provided. In particular, the present disclosure provides methods and compositions for modulating WNT (Wingless and lnt-1) signaling in a subject to modulate regeneration of tear-producing acinar cells to treat aqueous-deficient type dry-eye diseases. Further disclosed are WNT signaling modulators used in the methods.
Claims42
A method of regenerating lacrimal gland cells in a subject, comprising administering a WNT signaling modulator to the subject.
A method of treating a lacrimal gland disorder in a subject, comprising administering a WNT signaling modulator to the subject.
A composition for the treatment of a dry-eye disorder in a subject, the composition comprising a WNT signaling modulator.
Dependencies are inferred from the claim text.