Humanized Anti-DNAM-1 Antibody
AssigneesUniversity of Tsukuba, TNAX Biopharma Corporation
InventorsAkira Shibuya, Kazuko Shibuya, Yumi Kanemaru, Fumie Abe
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Abstract
One aspect of the present invention is a humanized anti-DNAM-1 antibody or an antigen-binding fragment thereof, including: a heavy chain variable region containing an amino acid sequence of SEQ ID NO: 1 as HCDR1, an amino acid sequence of SEQ ID NO: 2 as HCDR2, and an amino acid sequence of SEQ ID NO: 3 as HCDR3; and a light chain variable region containing an amino acid sequence of SEQ ID NO: 4 as LCDR1, an amino acid sequence of SEQ ID NO: 5 as LCDR2, and an amino acid sequence of SEQ ID NO: 6 as LCDR3.
Claims23
A humanized anti-DNAM-1 antibody or an antigen-binding fragment thereof, comprising:
- a heavy chain variable region comprising an HCDR1 having the amino acid sequence of SEQ ID NO:
- 1, an HCDR2 having the amino acid sequence of SEQ ID NO:
- 2, and an HCDR3 having the amino acid sequence of SEQ ID NO:
- 3, wherein the heavy chain variable region comprises an amino acid sequence at least 90% identical to SEQ ID NO:
- 10;
- and
- a light chain variable region comprising an LCDR1 having the amino acid sequence of SEQ ID NO:
- 4, an LCDR2 having the amino acid sequence of SEQ ID NO:
- 5, and an LCDR3 having the amino acid sequence of SEQ ID NO:
- 6, wherein the light chain variable region comprises an amino acid sequence at least 90% identical to SEQ ID NO:
- 11.
Dependencies are inferred from the claim text.