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US 2025/0051441 A1Published application
Cd47/4-1bb-targeting protein complex and methods of use thereof
AssigneeFBD Biologics Limited
InventorsChun-Yu Lin, Shih-Han Huang, Yi-Chun HSIEH, Chi-Ling Tseng
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Abstract
This disclosure relates to protein complexes targeting CD47 and 4-1BB, and methods of use thereof. In one aspect, the protein complexes include one or more CD47-binding domains including all or a portion of the SIRPα extracellular regions, and one or more 4-1BB-binding domains including all or a portion of the 4-1BBL extracellular region.
Claims55
A protein complex, comprising:
- (a) an Fc;
- (b) a CD47-binding domain;
- and
- (c) a 4-1BB (tumor necrosis factor receptor superfamily member 9)-binding domain.
1 more element
A protein complex, comprising
- (a) a first polypeptide comprising from N-terminus to C-terminus:
- a first CD47-binding domain, an optional first hinge region, a first Fc region, an optional first linker peptide, a first 4-1BB-binding domain, and a second 4-1BB-binding domain;
- and
- (b) a second polypeptide comprising from N-terminus to C-terminus:
- a second CD47-binding domain, an optional second hinge region, a second Fc region, an optional second linker peptide, and a third 4-1BB-binding domain.
2 more elements
A protein complex, comprising
- (a) a first polypeptide comprising from N-terminus to C-terminus:
- a first CD47-binding domain, an optional first hinge region, a first Fc region, an optional first linker peptide, and a first 4-1BB-binding domain;
- and
- (b) a second polypeptide comprising from N-terminus to C-terminus:
- a second CD47-binding domain, an optional second hinge region, a second Fc region, an optional second linker peptide, and a second 4-1BB-binding domain.
2 more elements
A protein complex, comprising
- (a) a first polypeptide comprising from N-terminus to C-terminus:
- a first CD47-binding domain, a second CD47-binding domain, an optional first hinge region, and a first Fc region;
- and
- (b) a second polypeptide comprising from N-terminus to C-terminus:
- a first 4-1BB-binding domain, a second 4-1BB-binding domain, a third 4-1BB-binding domain, an optional second hinge region, and a second Fc region.
2 more elements
Dependencies are inferred from the claim text.