Cdh17 antibodies and methods of treating cancer
AssigneeThe Regents of the University of California
InventorsDennis Slamon, Martina S. McDermott, Neil A. O'Brien
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Abstract
The present disclosure provides antigen-binding proteins which bind to CDH17; bispecific antigen-binding proteins which bind to CDH17 and a second antigen; and conjugates thereof. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.
Claims45
An antigen-binding protein that specifically binds to human cadherin-17 (CDH17) comprising:
- a. CDRs 1-3 derived from a heavy chain variable region comprising the amino acid sequence:
- QVQLVQSGAEVKKPGSSVKISCKVSGYTFTDHTIHWMRQAPGQGLE WIGYIFPRDDIVVYAQKFQGRATLTADKSTSTAYMELSSLRSEDTAVY YCARPPYYYSRNFYFDYWGQGTTLTVSS (SEQ ID NO:
- 49) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity;
- and/or
- b. CDRs 1-3 derived from a light chain variable region comprising the amino acid sequence:
- DIQMTQSPSSLSASVGDRVTITCRVSSIISSSKLHWYQQKPGKAPKPLI YGTSTLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQWSNYPF TFGQGTKLEIK (SEQ ID NO:
- 50) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity.
An antigen-binding protein comprising
- a. CDRs 1-3 derived from a heavy chain variable region comprising the amino acid sequence:
- QVQLVQSGAEVKKPGASVKMSCKASGYTFTSYNMHWVRQAPGQGL EWIGAIYPGNGDTSYAQKFQGRATLTVDTSTSTAYMELSSLRSEDTA VYYCARGRGRYFEYWGQGTTLTVSS (SEQ ID NO:
- 45) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity;
- and/or
- b. CDRs 1-3 derived from a light chain variable region comprising the amino acid sequence:
- DIQLTQSPSSLSASVGDRVTMTCRASSSVSSSYLHWYQQKPGKAPKLL IYSTSNLASGVPSRFSGSGSGTDYTLTISSVQPEDFATYYCQQYDSSPS TFGQGTKLEIK (SEQ ID NO:
- 46) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity.
An antigen-binding protein comprising:
- a. CDRs 1-3 derived from a heavy chain variable region comprising the amino acid sequence:
- QVQLVQSGAEVKKPGASVKVSCKASGYTFTDYYMNWVRQAPGQGL EWMGVIYPYSGGIGYAQKFQGRVTMTVDKSTSTAYMELSSLRSEDTA VYYCARGRGDYFGLFDFWGQGTTVTVSS (SEQ ID NO:
- 47) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity;
- and/or
- b. CDRs 1-3 derived from a light chain variable region comprising the amino acid sequence:
- DIQLTQSPSSLSASVGDRVTITCRATSSLSYIHWYQQKPGKAPKPLIYEI SKLASGVPSRFSGSGSGTDYTLTISSLQPEDFATYYCQQWNYPFTFGQ GTKLEIK (SEQ ID NO:
- 48) or a variant sequence thereof which differs by only one or two amino acids or which has at least or about 85% sequence identity.
5-6. (canceled)
8-12. (canceled)
An antigen-binding protein that specifically binds to human cadherin-17 (CDH17) comprising:
- a. a heavy chain CDR1 comprising the amino acid sequence of:
- GYTFXDXT (SEQ ID NO:
- 55) wherein X at position 5 is N, S, R, Q, A or T, and X at position 7 is H, W, Y or F;
- b. a heavy chain CDR2 comprising the amino acid sequence of:
- IFPRDDIV (SEQ ID NO:
- 14);
- c. a heavy chain CDR3 comprising the amino acid sequence of:
- ARPPYYYSRNFYFDY (SEQ ID NO:
- 15);
- d. a light chain CDR1 comprising the amino acid sequence of:
- SIISSSK (SEQ ID NO:
- 16);
- e. a light chain CDR2 comprising the amino acid sequence of:
- GTS (SEQ ID NO:
- 17);
- and
- f. a light chain CDR3 comprising the amino acid sequence of:
- QQWSNYPFT (SEQ ID NO:
- 18).
14-17. (canceled)
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24-25. (canceled)
28-31. (canceled)
33-42. (canceled)
44-49. (canceled)
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58-61. (canceled)
63-64. (canceled)
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69-72. (canceled)
74-76. (canceled)
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80-82. (canceled)
Dependencies are inferred from the claim text.