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US 2025/0051431 A2Published application
Antibody Variants
AssigneeTillotts Pharma AG
InventorEsther Maria FURRER
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Abstract
The present invention relates to antibodies which bind to TNFα and comprise a modified Fc region. The antibodies of the invention have improved resistance against proteolytic degradation and good effector functions and/or pharmacokinetic properties.
Claims18
An antibody comprising a TNFα-binding domain and an FcRn binding site, wherein the amino acid sequence of the antibody comprises:
- (i) the amino acids 233P, 234V, 235A, and a deletion at amino acid position 236;
- and
- (ii) either the amino acid 434A or the amino acids 252Y, 254T and 256E, wherein the numbering of amino acid residues is according to the EU index.
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Dependencies are inferred from the claim text.