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AssigneesInstitut National de la Sante et de la Recherche Medicale, Assistance Publique-Hopitaux de Paris, Sorbonne Universite, Université Paris Cité
InventorsGuido KROEMER, Omar MOTIÑO GARCIA-MIGUEL
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Insults to vital organs have serious and even life-threatening consequences. Organ insults have different etiologies and typically include drugs, toxins and ischemic insults. Acyl-CoA binding protein (ACBP), also known as diazepam-binding inhibitor (DBI), is an extracellular feedback regulator of autophagy. Here, the inventors report that injection of a monoclonal antibody neutralizing ACBP/DBI (α-DBI) protects the murine liver against ischemia/reperfusion damage, acute intoxication by acetaminophen and concanavalin A, as well as against liver fibrosis induced by bile duct ligation or carbon tetrachloride. Of note, the results support the contention that α-DBI mediates broad organ-protective effects against multiple insults. Thus, the present invention relates to methods and pharmaceutical composition of protecting organs from injuries comprising neutralization of Acyl-CoA Binding Protein.
A method of treating tissue damage caused by chemical injury, physical injury, or ischemic injury in an organ of a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an agent that inhibits the activity or expression of diazepam binding inhibitor (DBI), wherein the administering is sufficient to treat the tissue damage in the organ of the subject caused by chemical injury, physical injury, or ischemic injury.
A method of reducing the severity of an injury in an isolated organ, the method comprising contacting the isolated organ with an agent that inhibits the activity or expression of diazepam binding inhibitor (DBI) in an amount sufficient to reduce the severity of the injury in the isolated organ.
A method of reducing fibrosis associated with an organ injury in a subject in need thereof, the method comprising administering to the subject a therapeutically effect amount of an agent that inhibits the activity or expression of diazepam binding inhibitor (DBI), wherein the administering is sufficient to reduce an amount of the fibrosis associated with the organ injury in an organ of the subject, as compared to an amount of fibrosis in the organ in the absence of the administrating.
A method of treating tissue damage caused by chemical injury, physical injury, or ischemic injury in a liver or a heart of a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an agent that inhibits the activity or expression of diazepam binding inhibitor (DBI), wherein the administering is sufficient to treat tissue damage in the liver or the heart of the subject caused by the chemical injury, physical injury, or ischemic injury.
Dependencies are inferred from the claim text.