Anti-a-beta protein antibodies, methods and uses thereof
AssigneeHoffmann-La Roche Inc.
InventorsPer-Ola FRESKGARD, Guy GEORGES, Sabine IMHOF-JUNG, Markus NEUBAUER, Jens NIEWOEHNER, Petra RUEGER
Life of this patent
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Abstract
Herein is reported an antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from (1) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 83; or (2) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 83; or (3) CDRs of SEQ ID NO: 85, 86, 87, 81, 82 and 91; or (4) CDRs of SEQ ID NO: 85, 89, 87, 81, 82 and 91.
Claims15
An antibody that binds to human A-beta protein, wherein the antibody comprises a heavy chain variable domain (VH) and a light chain variable domain comprising CDRs selected from
- (1)
- (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 85;
- (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 86;
- (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 87;
- (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 81;
- (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 82;
- and
- (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 83;
- or
- (2)
- (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 85;
- (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 89;
- (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 87;
- (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 81;
- (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 82;
- and
- (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 83;
- or
- (3)
- (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 85;
- (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 86;
- (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 87;
- (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 81;
- (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 82;
- and
- (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 91;
- or
- (4)
- (a) a CDR-H1 comprising the amino acid sequence of SEQ ID NO:
- 85;
- (b) a CDR-H2 comprising the amino acid sequence of SEQ ID NO:
- 89;
- (c) a CDR-H3 comprising the amino acid sequence of SEQ ID NO:
- 87;
- (d) a CDR-L1 comprising the amino acid sequence of SEQ ID NO:
- 81;
- (e) a CDR-L2 comprising the amino acid sequence of SEQ ID NO:
- 82;
- and
- (f) a CDR-L3 comprising the amino acid sequence of SEQ ID NO:
- 91.
Dependencies are inferred from the claim text.