Antibodies to amyloid beta
AssigneesThe University of British Columbia, ProMIS Neurosciences Inc.
InventorsNeil R. Cashman, Steven S. Plotkin, Judith Maxwell Silverman, Ebrima Gibbs, Johanne Kaplan
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Abstract
The disclosure pertains to antibodies that bind A-beta oligomers and methods of making and using said antibodies.
Claims56
An isolated antibody comprising a light chain variable region and a heavy chain variable region, optionally fused, the heavy chain variable region comprising complementarity determining regions CDR-H1, CDR-H2 and CDR-H3, the light chain variable region comprising complementarity determining region CDR-L1, CDR-L2 and CDR-L3 and with the amino acid sequences of said CDRs comprising or consisting of the sequences SEQ ID Nos:
- 1-6;
- or SEQ ID Nos:
- 1,2, 80 and 4-6, or SEQ ID Nos:
- 1, 2, 80-83.
A humanized antibody comprising a sequence as set forth in Table 4A or 4B or a sequence with at least 50% sequence identity thereto wherein the CDR amino acid sequences are as set for forth in SEQ ID NO:
- 1-6;
- SEQ ID Nos:
- 1, 2, 80, 4-6;
- SEQ IDS Nos:
- 1, 2, 80-83 or SEQ ID Nos:
- 74-79.
Dependencies are inferred from the claim text.