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US 2025/0051425 A1Published application
Antibodies having pan-antiviral activity and methods thereof
AssigneeYale University
InventorsAkiko Iwasaki, Yexin Yang
Life of this patent
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Abstract
Described herein are antibodies having pan-antiviral activity. In certain embodiments, the antibodies recognize glycosylation patterns specific to viral proteins, but not found on host proteins. Also described herein are methods of preventing, treating, and/or ameliorating viral infections using the antibodies of the disclosure.
Claims20
An isolated antigen-binding protein comprising a light chain polypeptide and a heavy chain polypeptide, wherein
- the light chain polypeptide comprises:
- a complementarity determining region (CDR) 1 comprising the amino acid sequence of SEQ ID NO:
- 1;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 2;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 3, and
- the heavy chain polypeptide comprises:
- a CDR 1 comprising the amino acid sequence of SEQ ID NO:
- 4;
- a CDR2 comprising the amino acid sequence of SEQ ID NO:
- 5;
- and
- a CDR3 comprising the amino acid sequence of SEQ ID NO:
- 6.
13 more elements
Dependencies are inferred from the claim text.