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US 2025/0051423 A1Published application
Polyomavirus neutralizing antibodies
AssigneeNovartis AG
InventorsJohanna ABEND, Zorica DRAGIC, Adam Lloyd FEIRE, Mark KNAPP, Steven KOVACS, Elisabetta TRAGGIAI, Lichun WANG, Yongqiang WANG, Danqing WU, Qilong WU, Fangmin XU
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Abstract
The present invention relates to anti-VP1 antibodies, antibody fragments, and their uses for the prevention and treatment of polyoma virus infection and associated diseases.
Claims21
1-47. (canceled)
An isolated antibody or antigen binding fragment thereof comprising:
- (i) a heavy chain variable region (vH) that comprises (a) a HCDR1 (CDR-Complementarity Determining Region) of SEQ ID NO:
- 246, (b) a HCDR2 of SEQ ID NO:
- 247, and (c) a HCDR3 of SEQ ID NO:
- 248, and a light chain variable region (vL) that comprises:
- (d) a LCDR1 of SEQ ID NO:
- 256, (e) a LCDR2 of SEQ ID NO:
- 257, and (f) a LCDR3 of SEQ ID NO:
- 258;
- (ii) a heavy chain variable region (vH) that comprises (a) a HCDR1 of SEQ ID NO:
- 266, (b) a HCDR2 of SEQ ID NO:
- 267, and (c) a HCDR3 of SEQ ID NO:
- 268, and a light chain variable region (vL) that comprises:
- (d) a LCDR1 of SEQ ID NO:
- 276, (e) a LCDR2 of SEQ ID NO:
- 277, and (f) a LCDR3 of SEQ ID NO:
- 278;
- or
- (iii) a heavy chain variable region (vH) that comprises (a) a HCDR1 of SEQ ID NO:
- 286, (b) a HCDR2 of SEQ ID NO:
- 287, and (c) a HCDR3 of SEQ ID NO:
- 288, and a light chain variable region (vL) that comprises:
- (d) a LCDR1 of SEQ ID NO:
- 296, (e) a LCDR2 of SEQ ID NO:
- 297, and (f) a LCDR3 of SEQ ID NO:
- 298.
22 more elements
Dependencies are inferred from the claim text.