Polypeptide modulators
AssigneeGeorgiamune Inc.
InventorsSAMIR KHLEIF, Mikayel MKRTICHYAN
Life of this patent
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Abstract
Isolated polypeptides are described, which are mutants of programmed death 1 ligand 2 (“PD-L2”) and can either activate or suppress immune cells through activating or suppressing programmed cell death protein 1 (“PD-1”). Also described are isolated polypeptides that block the activating or inhibitory site of PD-L2, thereby inhibiting or activating PD-1. Further described are pharmaceutical compositions including the polypeptides and methods of using the polypeptides.
Claims45
An isolated polypeptide comprising an amino acid sequence which is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical to SEQ ID NO:
- 1.
An isolated polypeptide comprising an amino acid sequence which is SEQ ID NO:
- 21.
An isolated polypeptide comprising an amino acid sequence which is SEQ ID NO:
- 22.
18-42. (canceled)
An isolated polypeptide comprising an amino acid sequence which is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical to any one of SEQ ID NOS:
- 11-13.
An isolated polypeptide comprising an amino acid sequence which is at least 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 99% identical to SEQ ID NO:
- 14.
53-70. (canceled)
Dependencies are inferred from the claim text.