Altering cytokine specificity through binding valency
AssigneeThe Regents of the University of California
InventorAaron S. MEYER
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Abstract
The present disclosure provides a multivalent biomolecule comprising three or more covalently linked common γ-chain receptor cytokines (e.g., IL-2, IL-4, IL-7, IL-9, IL-15 or IL-21, or an immunologically active fragment thereof). In one embodiment, the common γ-chain receptor cytokines in the multivalent biomolecule are expressed as Fc fusion proteins with an IgG1 Fc. The multivalent biomolecule presented herein can be used to activate or suppress immune responses in a subject.
Claims29
A multivalent biomolecule comprising three or more covalently linked common γ-chain receptor cytokines.
A multivalent cytokine of any one of SEQ ID NOs:2, 4-8, 10, 12, 17-25 or 34-75.
A multivalent cytokine comprising a multimer of any one of SEQ ID NOs:9, 10, 58, 60, 11, 74, 62, 64, 66, 68, 70, 72 or 74, or any combination thereof.
A nucleic acid encoding any one of SEQ ID NOs:2, 4-8, 10, 12, 17-22, 34-57, 58, 60, 62, 64, 66, 68, 70, 72 or 74.
A vector comprising a nucleic acid encoding any one of SEQ ID NOs:2, 4-8, 10, 12, 17-22, 34-57, 58, 60, 62, 64, 66, 68, 70, 72 or 74.
Dependencies are inferred from the claim text.