Lilrb polypeptides and uses thereof
AssigneeKAHR Medical Ltd.
InventorsAmi TAMIR, Itai BLOCH
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Abstract
LILRB polypeptides are provided. Accordingly, there is provided a LILRB polypeptide capable of binding an HLA-G polypeptide as set forth in SEQ ID NO: 3 and having at least one mutation located within amino acid positions 40-60 of a D1 domain of LILRB, wherein the LILRB polypeptide has an increased stability and/or increased affinity to HLA-G compared to a LILRB polypeptide of the same length and sequence not comprising the at least one mutation. Also provided are polynucleotides encoding the LILRB polypeptide, host cells expressing the LILRB polypeptide and methods of producing and using same.
Claims32
A LILRB polypeptide capable of binding an HLA-G polypeptide as set forth in SEQ ID NO:
- 3 and having at least one mutation located within amino acid positions 40-60 of a D1 domain of LILRB, wherein said LILRB polypeptide has an increased stability and/or increased affinity to said HLA-G compared to a LILRB polypeptide of the same length and sequence not comprising said at least one mutation.
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Dependencies are inferred from the claim text.