Antimicrobial peptides, variants and chemical analogues thereof and their uses

An isolated peptide, a variant or a chemical analogue thereof, wherein

• (i) the isolated peptide and the variant thereof are selected from:
• a) peptide consisting in any one of sequences selected from SEQ ID NO:
• 2 to SEQ ID NO:
• 11;
• b) peptide comprising a sequence selected from any one of SEQ ID NO:
• 2 to SEQ ID NO:
• 11;
• c) peptide as defined in a) or b) and comprising a modifying group of its C-terminal carboxyl group and/or of its N-terminal amine group;
• d) peptide having at least 80% or at least 90% identity with peptide as defined in a), b) or c) and
• e) retro and retro-inverso peptide of peptides as defined in a) to d),
• (ii) the chemical analogues are selected from:
• f) a chemical analogue consisting in any one of sequences selected from SEQ ID NO:
• 13 and SEQ ID NOs:
• 15 to 19;
• g) a chemical analogue comprising a sequence selected from any one of SEQ ID NO:
• 13 and SEQ ID Nos:
• 15 to 19;
• h) a chemical analogue as defined in f) or g) and comprising a modifying group of its C-terminal carboxyl group and/or of its N-terminal amine group,
• i) a chemical analogue having at least 80% or at least 90% identity with analogues having sequences SEQ ID NO:
• 13 and SEQ ID NO:
• 16-19 as defined in f), g) or h) or having at least 90% identity with analogues having sequence SEQ ID NO:
• 15 as defined in f), g) or h);
• j) retro and retro-inverso peptide of peptides as defined in f) to i),
• said peptide and variants as defined in a) to e) and said chemical analogues as defined in f) to j) having an antimicrobial activity.