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US 2025/0051396 A1Published application
Modified viral capsids
OwnerTomas BJÖRKLUND, Marcus DAVIDSSONinventors
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Abstract
Provided are methods for identifying polypeptides that when displayed on a capsid confer a desired property to viral particles including such capsids, as well as methods for designing and manufacturing viral vectors and viral particles with improved properties.
Claims18
A viral vector encoding a viral particle for delivery of a transgene to a target cell, said viral vector comprising a modified capsid gene and a transgene to be delivered to the target cell;
- wherein the modified capsid gene is outside a viral genome and comprises a polynucleotide encoding a polypeptide, wherein said polypeptide improves the delivery of the transgene and/or targeting to the target cell, and
- wherein said polypeptide comprises or consists of any one of SEQ ID NO:
- 1 to SEQ ID NO:
- 50.
1 more element
A modified viral particle for delivery of a transgene to a target cell, said modified viral particle comprising a modified capsid and a transgene to be delivered to a host cell;
- wherein the modified capsid improves one or more of:
- delivery of the transgene to the target cell, targeting to the target cell, infectivity of the viral particle, and/or retrograde transport of the modified viral particle compared to an unmodified viral particle comprising a native capsid gene and the transgene, and the modified capsid gene is outside the viral genome,
- wherein the modified capsid comprises a polypeptide, and
- wherein said polypeptide comprises or consists of any one of SEQ ID NO:
- 1 to SEQ ID NO:
- 50.
3 more elements
Dependencies are inferred from the claim text.