Bicyclic peptide ligands specific for nectin-4
AssigneeBicycleTx Limited
InventorsStephen J. Blakemore, Tara Gelb, Nicholas Keen, Michael Rigby
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Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of Nectin-4. The invention also includes drug conjugates comprising said peptides, conjugated to one or more effector and/or functional groups, to pharmaceutical compositions comprising said peptide ligands and drug conjugates and to the use of said peptide ligands and drug conjugates in preventing, suppressing or treating a disease or disorder mediated by Nectin-4.
Claims21
-23. (canceled)
A method comprising:
- selecting a patient having a Nectin-4 copy number of more than two in a tumor tissue;
- and
- administering to the patient a drug conjugate targeting Nectin-4.
A method comprising:
- administering to a patient a drug conjugate targeting Nectin-4, wherein the patient has been diagnosed as having a Nectin-4 copy number of more than two in a tumor tissue.
Dependencies are inferred from the claim text.