US 2025/0051390 A1 · NOVEL ADIPONECTIN-DERIVED PEPTOID DERIVATIVE AND USE THEREOF

Abstract

The present invention relates to a novel peptoid derivative and the like. The peptoid derivative is obtained by partially modifying an adiponectin receptor peptide, and has high stability and excellent p-AMPK activity, compared to existing adiponectin receptor peptides and has improved physical properties and activity, thus having the advantage of being suitable for drug formulation. Therefore, the peptoid derivative of the present invention can be used for the prevention or treatment of skin inflammatory diseases, wounds, hair loss, fibrosis, metabolic diseases, or cancer, or the prevention or amelioration of aging, sensitive skin, wrinkles, or moisturization.

Claims10

Dependent claims

A peptoid derivative represented by [Chemical Formula 1]below:

in [Chemical Formula 1],
R1 is at least one selected from the group consisting of an amino group (NH2), an acetylamino group (Ac-NH), NH2—(CH2CH2O)m—CH2CONH, a C15-C20 amide group, and combinations thereof (wherein m is an integer of 1 to 5),
R2 is at least one selected from the group consisting of a C1-C6 acyclic alkyl group, a C1-C6 cyclic alkyl group, a C2-C6 alkylcarboxyl group, and combinations thereof, and
R3, R4, and R5 are the same as or different from each other, and are each independently a C7-C12 phenylalkyl group, a pyridinylmethyl group, an indolylmethyl group, and a benzodioxolomethyl group,
wherein the phenylalkyl group is unsubstituted or at least one selected from the group consisting of a hydroxyl group, a trifluoromethyl (CF3) group, a halogen group, a cyano group, a nitro group, a C1-C6 acyclic alkyl group, a C1-C6 alkoxy group, and combinations thereof.

2 more elements

Dependencies are inferred from the claim text.

Novel adiponectin-derived peptoid derivative and use thereof

Life of this patent

Novel adiponectin-derived peptoid derivative and use thereof

Life of this patent

Abstract

Claims10