Steroid derivative regulators, method for preparing the same, and uses thereof

A compound of formula (IV), the stereoisomer thereof, or the pharmaceutically acceptable salt thereof:

• wherein:
• Z is selected from the group consisting of —CR23R24—, —(CH2)n1NR23— and —CH2O—;
• ring A is selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• each Ra is identical or different and each is selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, amino, nitro, hydroxy, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1C(O)R23, —(CH2)n1C(O)OR23, —(CH2)n1S(O)m1R23, —(CH2)n1S(O)(NR23)R24, —(CH2)n1NR23R24, —(CH2)n1C(O)NR23R24, —(CH2)n1NR23C(O)R23 and —(CH2)n1NR23S(O)m1R24, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• R15a is selected from the group consisting of alkyl, haloalkyl, alkoxy, halogen, amino, hydroxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1S(O)m1R23 and —(CH2)n1NR23R24, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• R16a is selected from the group consisting of hydrogen atom, alkyl, haloalkyl, alkoxy, halogen, amino, hydroxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R23, —(CH2)n1OR23, —(CH2)n1SR23, —(CH2)n1S(O)m1R23 and —(CH2)n1NR23R24;
• or, R15a and R16a form a cycloalkyl or heterocyclyl, wherein the cycloalkyl or heterocyclyl is optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, and R15a and R16a are not hydrogen at the same time;
• R23 and R24 are each selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, alkoxy, haloalkoxy, halogen, amino, nitro, hydroxy, cyano, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, haloalkyl, halogen, amino, oxo, nitro, cyano, hydroxy, alkenyl, alkynyl, alkoxy, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, —(CH2)n1R25, —(CH2)n1OR25, —(CH2)n1SR25, —(CH2)n1C(O)R25, —(CH2)n1C(O)OR25, —(CH2)n1S(O)m1R25, —(CH2)n1NR25R26, —(CH2)n1C(O)NR25R26, —(CH2)n1C(O)NHR25, —(CH2)n1NR25C(O)R26 and —(CH2)n1NR25S(O)m1R26;
• R25 and R26 are identical or different and are each independently selected from the group consisting of hydrogen atom, deuterium atom, alkyl, deuterated alkyl, haloalkyl, hydroxy, amino, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are each optionally further substituted by one or more substituents selected from the group consisting of deuterium atom, alkyl, halogen, hydroxy, amino, oxo, nitro, cyano, alkenyl, alkynyl, alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
• x is an integer of 0, 1, 3, 4 or 5;
• m1 is an integer of 0, 1 or 2;
• and
• n1 is an integer of 0, 1, 2, 3, 4 or 5.