Neutral glycosylated amides and dianionic glucuronidated acids as stabilizers for biological molecules

A compound having the structure:

• wherein
• X is an uronic acid group selected from the group consisting of glucuronic acid, mannuronic acid, galacturonic acid, alluronic acid, altruronic acid, guluronic acid, iduronic acid and taluronic acid, or an uronic acid amide group selected from the group consisting of Glucuronamide, mannuronamide, galacturonamide, alluronamide, altruronamide, guluronamide, iduronamide and taluronamide;
• each of R1 and R2 is independently H, halogen, OH, O-alkyl, CONH2, CO2H, CO2-alkyl, or optionally substituted alkyl;
• each of Y and Z is independently H, OH, O-alkyl or optionally substituted alkyl;
• m is 0, 1 or 2;
• and
• A =NR3R4 or OR5,
• wherein
• each of R3 and R4 is independently H, OH, O-alkyl or optionally substituted alkyl;
• R5 is independently H or optionally substituted alkyl;
• wherein
• when X is glucosyl, then R1 is optionally substituted alkyl,
• when each of R1 and R2 is H and m is 0, then X is other than glucuronic acid, and
• wherein when X is glucosyl or mannosyl, m=0, one of R1 or R2 is -alkyl-OH and the other is —H, and A is —NH2, then the compound is a beta-anomer;
• or a salt thereof.