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US 2025/0051332 A1Published application
Opioid receptor agonist and methods of use thereof
AssigneeThe Board of Trustees of the University of Illinois
InventorsANDREW RILEY, RICHARD VAN RIJN, ANNA GUTRIDGE, SIMONE CREED
Life of this patent
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Abstract
In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, the disclosure, in one aspect, relates to compounds that can bind to one or more opioid receptors. In one aspect, the compounds described herein can bind to the kappa opioid receptor (κOR) and behave as an opioid receptor agonist. The ability of the compounds to bind to opioid receptors make them effective in the treatment or prevention of pain such as chronic pain.
Claims20
A compound of formula I
- or a pharmaceutically acceptable salt thereof,
- wherein
- each independently represents a single or double bond;
- R1 is absent when is a double bond or R1 is hydrogen, hydroxyl, or acetyloxy when is a single bond;
- R2 is hydrogen;
- R3 is absent when is a double bond or is hydrogen, hydroxyl, or acetyloxy when is a single bond, or R2 and R3 together form a carbonyl group when is a single bond;
- R4 is hydrogen, substituted or unsubstituted alkyl, or aralkyl;
- R6 and R7 are alkyl;
- and
- R5 is selected from hydrogen, hydroxy, alkoxy, hydroxyalkyl, alkoxyalkyl, halide, haloalkyl, nitrile, nitro, amino, amido, acetyl, acetylamino, acetyloxy, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein at least one of R5 is not hydrogen;
- n is 1, 2, 3, or 4;
- and
- R8 is absent or is a substituted or unsubstituted alkyl, an alkenyl group, a cycloalkyl group, or an aralkyl group,
- provided the compound of formula I does not include:
11 more elements
The compound of claim 9, wherein R7 is a C1 to C5 alkyl group.
Dependencies are inferred from the claim text.