US 2025/0051323 A1 · BICYCLIC AMINE DERIVATIVES AS GABAA alpha5 RECEPTOR MODULATORS

Abstract

The present invention provides compounds of formula (I) and/or salts thereof and/or stereoisomers thereof and/or enantiomers thereof and/or racemates thereof and/or diastereomers thereof and/or biologically active metabolites thereof and/or prodrugs thereof and/or solvates thereof and/or hydrates thereof and/or polymorphs thereof having affinity and selectivity for the gamma-aminobutyric acid A receptor subunit alpha 5 and act as GABAA α5 positive allosteric modulators, thereby useful in the treatment or prevention of diseases related to the GABAA α5 receptor, process for the preparation and intermediates of the preparation process thereof, pharmaceutical compositions comprising them alone or in combination with one or more other active ingredients and their use as medicaments.

Claims20

Dependent claims

A compound of formula (I)

wherein
A is represented by
group, or
group;
R1 is an alkyl, an alkoxy, or a haloalkyl group;
R2 is hydrogen;
an alkyl group optionally substituted with —S(O)2-alkyl, cycloalkyl or heterocycle;
a cycloalkyl group;
a heterocycle group optionally substituted with an alkyl;
or a heteroaryl group;
X is CH, or N;
or pharmaceutically acceptable salts thereof.

9 more elements

Dependencies are inferred from the claim text.

BICYCLIC AMINE DERIVATIVES AS GABAA alpha5 RECEPTOR MODULATORS

Life of this patent

BICYCLIC AMINE DERIVATIVES AS GABAA alpha5 RECEPTOR MODULATORS

Life of this patent

Abstract

Claims20