Crystal of substituted piperidine compound, salts of substituted piperidine compound, and crystals thereof

A crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide mono D-tartrate represented by formula (II):

• or
• a crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide hemioxalate represented by formula (III):

A Form α crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having one or more diffraction peaks selected from the group consisting of diffraction angles (2θ±0.2°) of 12.2°, 12.8°, 15.5°, 21.2° and 24.6° in a powder X-ray diffraction.

-7. (canceled)

A Form α crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having peaks at chemical shifts (δ±0.5 ppm) of 49.2 ppm, 67.6 ppm and 72.5 ppm in a solid state 13C NMR spectrum.

-10. (canceled)

A Form α crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having Raman shift peaks (±2 cm−1) at 842.1 cm−1, 895.0 cm−1 and 1199.4 cm−1 in Raman spectrophotometry.

(canceled)

A Form β crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having one or more diffraction peaks selected from the group consisting of diffraction angles (2θ±0.2°) of 4.9°, 9.8°, 11.8°, 14.6° and 16.1° in a powder X-ray diffraction.

-17. (canceled)

A Form β crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having peaks at chemical shifts (δ±0.5 ppm) of 74.1 ppm, 159.2 ppm and 177.7 ppm in a solid state 13C NMR spectrum.

-20. (canceled)

A Form β crystal of (2R)-2-cyclopropyl-2-{(1R,3S,5S)-3-[(3S,4R)-1-(5-fluoropyrimidin-2-yl)-3-methoxypiperidin-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}acetamide represented by formula (I):

• having Raman shift peaks (±2 cm−1) at 889.9 cm−1, 1089.4 cm−1 and 1194.6 cm−1 in Raman spectrophotometry.

(canceled)

-27. (canceled)

(canceled)

-34. (canceled)

-37. (canceled)