Benzazepine derivatives
AssigneeOtsuka Pharmaceutical Co., Ltd.
InventorsKeizo KAN, Masatoshi TAKUWA, Hirotaka TANAKA, Hideto FUJIWARA, Hokuto YAMABE, Satoshi MATSUDA, Kazuhiro OHDACHI, Taiki HANARI, Yasuhiro MENJO, Tatsuya URUSHIMA, Shigekazu FUJITA
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Abstract
Provided are novel benzazepine compounds of Formula (1), or salts thereof, having vasopressin V1a and V2 antagonisms, and medical uses thereof, in the formula, R1 is optionally substituted C1-6 alkyl, etc.; L is —C(═O)—NH—, etc.; Ring A1 is a hydrocarbon ring, etc.; Ring A2 is a hydrocarbon ring, etc.; and each of Rings A1 and A2 may have at least one substituent.
Claims14
A method of treating, preventing, and/or diagnosing a disease selected from the group consisting of Meniere's disease, hypertension, edema, ascites, heart failure, renal dysfunction, renal failure, polycystic kidney disease, syndrome of inappropriate vasopressin secretion, hepatic cirrhosis, hyponatremia, hypokalemia, diabetes, circulation insufficiency, kinesia, water metabolism disorder, and ischemic disorder, comprising administering to a subject a benzazepine compound of Formula (1):
- wherein R1 is deuterium, OH, COOH, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkyl-O—CO—, or optionally substituted C2-6 alkenyl;
- L is a direct bond or —C(═O)—NH—;
- Ring A1 is a hydrocarbon ring or heterocycle;
- Ring A2 is a hydrocarbon ring or heterocycle;
- and
- each of Rings A1 and A2 may have at least one substituent,
- or a salt thereof.
A pharmaceutical composition comprising a benzazepine compound of Formula (1):
- wherein R1 is deuterium, OH, COOH, optionally substituted C1-6 alkyl, optionally substituted C1-4 alkyl-O—CO—, or optionally substituted C2-6 alkenyl;
- L is a direct bond or —C(═O)—NH—;
- Ring A1 is a hydrocarbon ring or heterocycle;
- Ring A2 is a hydrocarbon ring or heterocycle;
- and
- each of Rings A1 and A2 may have at least one substituent,
- or a salt thereof, and
- a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.