Mutant idh1 and idh2 inhibitor and application thereof
OwnerYabin Li, Xiaofeng Xu +7inventors
InventorsYabin Li, Xiaofeng Xu, Xizhen Song, Jingwei Ding, Yunlai Zhang, Jie Chen, Xiangyong Liu, Lieming Ding, Jiabing Wang
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Abstract
Disclosed are a compound represented by formula (I) as a mutant isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) inhibitor, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed is a use of the described compound or the pharmaceutical composition thereof in the treatment of mutant IDH1 and IDH2-mediated diseases.
Claims20
A compound represented by formula (VIb), or a pharmaceutically acceptable salt, solvate, chelate, non-covalent complex or prodrug thereof, wherein the compound represented by formula (VIb) has a structure of
- wherein
- R is selected from halogen and C1-C4 haloalkyl;
- R2 and R3 are independently selected from C1-C4 alkyl or C3-C6 cycloalkyl, wherein the C1-C4 alkyl and C3-C6 cycloalkyl are optionally substituted with one or more of hydrogen, halogen, oxo, —NO2, —OH, —NH2, —CN, C1-C4 alkyl, —O—C1-C4 alkyl, —NH(C1-C4 alkyl) or —N(C1-C4 alkyl)2;
- or R2 and R3 together with the carbon atom to which they are attached form cyclopropane and cyclobutane;
- and the cyclopropane and cyclobutane are optionally substituted with one or more of hydrogen or halogen;
- R5 and R6 are independently selected from C1-C4 alkyl or C3-C6 cycloalkyl, wherein the C1-C4 alkyl and C3-C6 cycloalkyl are optionally substituted with one or more of hydrogen, halogen, oxo, —NO2, —OH, —NH2, —CN, C1-C4 alkyl, —O—C1-C4 alkyl, —NH(C1-C4 alkyl) or —N(C1-C4 alkyl)2;
- or R5 and R6 together with the carbon atom to which they are attached form cyclopropane and cyclobutane;
- and the cyclopropane and cyclobutane are optionally substituted with one or more of hydrogen or halogen.
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-36. (canceled)
Dependencies are inferred from the claim text.