Continuous flow chemistry for synthesis of cannabinoids
AssigneeColorado Chromatography, LLC
InventorsGiovanni A. RAMIREZ, Tesfay T. TESFATSION, Ivan CRUCES, Adam J. HELLMANN, Kyle P. RAY, Westley CRUCES
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Abstract
Continuous flow chemistry processes are disclosed herein. The continuous flow processes can be used to produce tetrahydrocannabinol from a cannabidiol starting material. The continuous flow processes can also be used to produce hexahydrocannabinol from a tetrahydrocannabinol starting material. Multiple flow chemistry reactor systems can be combined to produce hexahydrocannabinol from a cannabidiol starting material. The continuous flow processes can be used to produce the desired products at kilogram scales within minutes.
Claims24
A continuous flow process for producing tetrahydrocannabinol from a cannabidiol starting material, the process comprising:
- mixing a cannabidiol starting material with a solvent to form a solution;
- adding an acid to the solution to form a reaction solution;
- feeding the reaction solution through a continuous flow loop;
- and
- passing the reaction solution through an energizing component to produce tetrahydrocannabinol.
A continuous flow process for producing hexahydrocannabinol from a tetrahydrocannabinol starting material, the process comprising:
- mixing a tetrahydrocannabinol starting material with a solvent to form a first solution;
- feeding the first solution into a continuous flow loop;
- feeding hydrogen gas into the continuous flow loop to form a combined feed comprising the hydrogen gas and the first solution;
- and
- passing the combined feed over a catalyst bed within the continuous flow loop to produce hexahydrocannabinol.
A bifurcated continuous flow process for producing hexahydrocannabinol from a cannabidiol starting material, the process comprising:
- mixing a cannabidiol starting material with a solvent to form a solution;
- adding an acid to the solution to form a reaction solution;
- feeding the reaction solution through a first continuous flow loop;
- passing the reaction solution through an energizing component to produce tetrahydrocannabinol;
- feeding the reaction solution comprising tetrahydrocannabinol through a second continuous flow loop;
- feeding hydrogen gas into the second continuous flow loop to form a combined feed comprising the hydrogen gas and the reaction solution comprising tetrahydrocannabinol;
- and
- passing the combined feed over a catalyst bed within the second continuous flow loop to produce hexahydrocannabinol.
Dependencies are inferred from the claim text.