Method for preparing 4-nitro-2-(trifluoromethyl)acetophenone and application thereof

A method for preparing a compound of formula (I), comprising:

• (i) reacting a compound (II) with a compound (III) in the presence of a base A to obtain a compound (IV);
• (ii) converting the compound (IV) into a compound (V) in the presence of a base B;
• and
• (iii) reacting the compound (V) with an oxidant to obtain the compound of formula (I);
• as shown in the following reaction scheme:
• wherein X1 is halogen;
• R1 is hydrogen, a C1-C10 alkyl group, a C6-C12 aryl group or a heteroaryl group containing one or two atoms selected from nitrogen, oxygen, and sulfur;
• and the C1-C10 alkyl group, the C6-C12 aryl group and the heteroaryl group are unsubstituted or substituted with halogen;
• the base A and the base B are each independently selected from the group consisting of an alkali metal carbonate, an alkali metal bicarbonate, an alkali metal phosphate, an alkali metal C1-C6 alkyl carboxylate, an alkali metal formate, an alkali metal hydroxide, an alkali metal alcoholate, an alkali metal hydride, an alkaline earth metal carbonate, an alkaline earth metal bicarbonate, an alkaline earth metal phosphate, an alkaline earth metal C1-C6 alkyl carboxylate, an alkaline earth metal formate, an alkaline earth metal hydroxide, an alkaline earth metal alcoholate, an alkaline earth metal hydride, an alkali metal alkylide, an alkali metal amide compound, an organic amine compound, and a mixture thereof;
• and
• the oxidant is selected from the group consisting of oxygen, air, ozone, peroxide compound, hypohalite, halate, perhalogenate, and a mixture thereof.