Method for synthesizing tyloxapol
AssigneeShenyang Xingqi Pharmaceutical Co., Ltd.
InventorsJidong LIU, Qiang YANG, Yu LEI, Bo WEN
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Abstract
The present invention provides a method for synthesizing tyloxapol of formula (I), including the following steps: first reacting p-tert-octylphenol of formula (III) with formaldehyde under alkaline conditions to obtain 2,5-dimethylol p-tert-octylphenol of formula (IV); then reacting 2,5-dimethylol p-tert-octylphenol with p-tert-octylphenol of formula (III) under acidic conditions to obtain the phenolic resin of formula (II); and finally, reacting the phenolic resin of formula (II) with ethylene oxide to obtain tyloxapol of formula (I).
Claims21
A compound of formula (I):
- wherein n is 6, 7, 8, 9, 10, 11 or 12;
- alternatively, n is 8, 9 or 10;
- yet alternatively, n is 9.
5-7. (canceled)
A compound of formula (II):
A method for preparing a compound of formula (IV),
- comprising the step of reacting the compound of formula (III) with formaldehyde under alkaline conditions to obtain the compound of formula (IV).
Dependencies are inferred from the claim text.