Method for the preparation of a composition comprising dissolved [18f]fluoride and composition obtainable by the method

Abstract

Provided is a method for the preparation of a composition comprising dissolved [18F]fluoride ions which is suitable for radiofluorination, said method comprising the steps of: providing an aqueous solution comprising water and [18F]fluoride ions; passing the aqueous solution through a solid phase extraction device comprising an anion exchange resin in order to trap [18F]fluoride ions on the anion exchange resin and to separate the [18F]fluoride ions trapped on the anion exchange resin from water; eluting [18F]fluoride ions from the anion exchange resin by passing an elution composition comprising an organic solvent and a salt of an alkanoic acid through the solid phase extraction device; obtaining a composition as an eluate which comprises the organic solvent, the salt of the alkanoic acid, and dissolved [18F]fluoride ions. Moreover, provided are the composition comprising dissolved [18F]fluoride ions, and a method for the preparation of a radiofluorinated organic compound, which involves the preparation of the composition comprising dissolved [18F]fluoride ions.

Dependencies are inferred from the claim text.