Chromatographic separation process for efficient purification of polyunsaturated fatty acids
AssigneeBASF SE
InventorsPedro SÁ GOMES, Angus MORRISON, Johan Fredrik BILLING, Iseabal MACARTHUR
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Abstract
The present invention relates to an improved chromatographic separation process for purification of a polyunsaturated fatty acid (PUFA) product and derivatives thereof. In particular, the present invention relates to a particularly efficient chromatographic separation process that employs silica having particular physical characteristics as an adsorbent phase for purifying a PUFA or derivative thereof from a feed mixture.
Claims18
-17. (canceled)
A chromatographic separation process for recovering a polyunsaturated fatty acid (PUFA) product from a feed mixture, which comprises introducing the feed mixture into a chromatography apparatus comprising one or more chromatographic columns containing:
- (a) a liquid eluent phase which is an aqueous organic solvent;
- and
- (b) a solid adsorbent phase which is a C18-bonded silica,
- wherein the pressure within the one or more chromatographic columns is less than 20 bar, thereby resulting in purification of the feed mixture,
- further wherein:
- (1) the silica has an average particle diameter of from 230 to 270 μm and a Dv(10) of 160 μm or greater;
- and/or
- (2) the silica has a carbon loading of from 15 to 24 wt %;
- and/or
- (3) the silica has a surface area of 500 m2/g or less.
Dependencies are inferred from the claim text.