Multi-needle intratumoral injection instrument

A surgical intratumoral injection system comprising:

• a guide catheter defining a lumen and configured to be navigated to a target;
• and
• a surgical intratumoral injection instrument configured to be inserted through the lumen of the guide catheter to access the target, the surgical intratumoral injection instrument including:
• a supply chamber configured to store a therapeutic agent;
• a handle assembly;
• a sleeve extending from the handle assembly and defining a lumen;
• a distal ring disposed at a distal end of the sleeve;
• a plurality of needle tines extending through the lumen of the sleeve and movable through the lumen of the sleeve via the handle assembly, wherein the plurality of needle tines is configured to dispense the therapeutic agent from the supply chamber;
• and
• a deflector extending through the lumen of the sleeve and movable through the lumen of the sleeve via the handle assembly, wherein retraction of the deflector relative to the sleeve and the plurality of needle tines causes the plurality of needle tines to deflect away from a central longitudinal axis of the sleeve against the distal ring to change an angle between a trajectory of the plurality of needle tines and the central longitudinal axis.

A surgical intratumoral injection instrument comprising:

• a supply chamber configured to store a therapeutic agent;
• a handle assembly;
• a sleeve extending from the handle assembly and defining a lumen;
• and
• a plurality of needle tines extending through the lumen of the sleeve and movable through the lumen of the sleeve via the handle assembly, wherein the plurality of needle tines is configured to dispense the therapeutic agent from the supply chamber to a tumor, and wherein the plurality of needle tines is formed of a shape memory material configured to splay radially outward from a central longitudinal axis of the sleeve when the plurality of needle tines is deployed from the sleeve and configured to curve inward toward the central longitudinal axis of the sleeve as the plurality of needle tines is inserted into the tumor.