Metered dose inhalers of fluticasone or an ester thereof

A metered dose inhaler comprising:

• a) a canister storing a pharmaceutical composition comprising (i) fluticasone propionate and (ii) a propellant comprising at least one of hydrofluoroalkane 227 or hydrofluoroalkane 134a, wherein:
• the fluticasone propionate is in suspended form in the pharmaceutical composition, and
• an internal surface of the canister is coated with a fluorocarbon polymer;
• b) a metering valve in fluid communication with the canister, the metering valve being configured to acquire a dose of the pharmaceutical composition from the canister, wherein the metering valve comprises one or more sealing gasket(s) made of ethylene propylene diene monomer or cyclic-olefin-copolymer or combination thereof;
• c) an actuator configured to receive the dose from the metering valve and to deliver the dose of the pharmaceutical composition to a user, wherein the actuator has:
• a spray orifice with a diameter of from about 550 μm to about 650 μm,
• a sump volume of from about 12 mm3 to about 20 mm3, and
• a jet length of from about 1.40 mm to about 1.60 mm;
• and
• d) a dose counter connected to the metering valve, the dose counter configured to indicate a number of doses remaining in the canister, wherein the dose counter is inside the actuator and is not connected to the canister.