A wearable transdermal drug applicator

A wearable transdermal drug applicator comprising:

• a dock for a liquid drug capsule;
• a dermal contact face;
• a delivery channel configured for delivering liquid from the drug capsule through a delivery port of the dermal contact face;
• a controller;
• a permeation enhancing subsystem interfacing the dermal contact face, the permeation enhancing subsystem comprising permeation enhancing elements operatively surrounding the delivery port and which are operative to enhance transdermal drug delivery at the dermal contact face, the elements comprising:
• a sonicator configured to apply ultrasound to skin contacting the dermal contact face;
• electrodes configured to configured to apply electric current to the skin contacting the dermal contact face;
• a heater configured to heat the skin contacting the dermal contact face;
• and
• red light LEDs configured to apply red light to the skin contacting the dermal contact face and wherein the controller is programmed with a delivery program and wherein the controller is configured for controlling the operation of the elements according to the delivery program.